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Biography

We investigate the impact of RNA nucleotide modifications in RNA-protein interactions.

Biography

We investigate how the neuropeptides oxytocin and vasopressin contribute to the neural regulation of behavior.

Biography

We investigate the molecular and biological processes governing the development of brain malignancies, including primary (e.g., glioblastoma) and metastatic (tumors originating from other locations in the body, such as breast cancer) brain cancers. Our goal is to develop novel immunotherapeutic strategies for patients with brain cancers.

Biography

We investigate and develop new methods and tools to record neurons in the brain using nonlinear microscopy and protein sensors. Our goals are to better understand the role of brain circuits and the efficacy of novel neuroprotective treatments in rodent models of neurodegenerative and neurological conditions.

Dr. Dana's Bibliography

Biography

We investigate the tumor suppression activity of an eIF2-associated glycoprotein, p67 in human cancer cells and in mice model.
 

Biography

We investigate early mechanisms of Alzheimer’s disease. Our goal is to discover how disruption of basic functions of the body can drive disease processes that destroy the brain. We study how integrin protein dysfunction is an early driver of AD pathology, and how AD pathology affects visual system signaling. 
Dr. Dengler-Crish's Lab Website

Biography

We investigate diabetes, cardiovascular diseases, inflammation, and stem cell-based gene therapy.

Biography

We investigate how obesity, diabetes, and metabolic syndrome affect the liver-gut-brain axis. We focus our studies on bile acid physiology and receptor signaling within the context of alcoholic and metabolic liver disease.

Biography

We investigate the effects of environmental stressors on the human thermal, metabolic and immunologic responses. 
Dr. Glickman's Lab Website

Biography

We investigate how the heart balances oxygen and nutrient delivery with its demands, aiming to understand key regulators that link oxygen supply with cardiac function. Our research focuses on identifying dysregulated mediators in disease and exploring cardioprotective mechanisms to discover therapeutic targets for cardiovascular disease.

Biography

We investigate interactions between the nervous system and immune systems that lead to alterations in behavior and cognitive functioning. We utilize in vivo and ex vivo approaches to investigate how environmental stressors and inflammatory stimuli impact mood, motivation, and learning.

Biography

We investigate the roles of the brain barriers (meninges, blood brain barrier and choroid plexus) in normal and pathological brain function. We particularly focus on immune-vascular interaction during neurodevelopment and neurodegeneration.

Biography

We investigate mechanobiology processes at the single-molecular, molecular assembly, and cellular level. We use optical tweezers to reveal interactions between individual nucleic acid structures and motor proteins (e.g. polymerases) from mechanical perspectives. At the cellular level, we strive to probe the effect of molecular machineries such as protein aggregates and organelles on cell mechanics such as migrations and divisions.

Biography

We investigate circadian rhythms of feeding and activity and how they interact with environmental stimuli.  We also study how disruption of circadian rhythms alters reproductive cycles.
Dr. Mintz's Lab Website

Biography

We investigate cells in the brain that regulate gonadotrophin-releasing hormone (GnRH) neurons, the final output cells in a large neural network controlling fertility. Our research is focused on identifying changes in these networks that underlie the development of common forms of infertility, such as polycystic ovary syndrome. 

Biography

We investigate how the brain modulates skeletal muscle thermogenesis—heat generation in muscle—and how this impacts energy balance and body weight. 
Dr. Novak's Lab Website

Biography

We are a bioinformatics lab, studying patterns of RNA editing in the context of host-pathogen interactions, and how RNA editing changes in brain health and disease. We currently focus on the role of ADAR editing changes in neurodegenerative and neuropsychiatric disorders, including Parkinson’s and Alzheimer diseases, and mental health disorders. 

Biography

Our lab develops translational therapies for regeneration and recovery after spinal cord injuries and discovers drugs to stop glioblastoma progression in mice, aiming to advance these into clinical trials

Biography

We investigate the inflammatory component of Alzheimer's disease using various mouse models. We are interested in microglia, the brain's resident immune cells, as well as components of the circulating peripheral immune system and their interactions with microglia, as well as how these cells may respond differently based on sex. 

Biography

We investigate how aging and neurological disorders limit movement in humans. Our current research examines the benefits of exercise and rehabilitation training on motor function in individuals with Parkinson's disease. Research methods used in human subjects research include movement assessment/evaluation, electromyography and Functional Near-Infrared Spectroscopy.  

Dr. Ridgel's Lab Website

Biography

We investigate brain circuits that modulate how we hear in different environments, during growth and aging, and after damage to the ear or the brain. We use sophisticated neural tracing methods to characterize neural circuits in rodents so we can understand how those circuits contribute to hearing.
 

Biography

We investigate microbiome-host interactions in the oral cavity, particularly in the setting of gum disease (one of the most prevalent inflammatory conditions worldwide) and comorbidities such as diabetes and oral cancer. We are specifically interested in how host diet and inflammation regulate microbe-microbe interactions within the oral microbiome and how these interactions in turn impact host fitness. Long-term, our goal is to translate our findings into more targeted microbiome-directed therapeutics.
 

Biography

We investigate major morphological transitions in evolution, focusing on whale evolution.  Our samples include fossil Eocene whales, as well as anatomical samples of modern bowhead and beluga whales.

Biography

We investigate how microbial symbionts shape the ecology and evolution of their vertebrate hosts. Our lab uses a combination of multi-omic techniques, germ-free animal experiments, and natural history studies to determine how intestinal microorganisms affect the phenotypes of wild vertebrates in nature. 

Dr. Trevelline's Lab Website

Biography

We investigate mechanisms by which emotional brain centers such as the amygdala interact with the auditory system to establish the meaning of speech and other social vocalizations. We seek to relate these mechanisms to acoustic communication behavior and to disorders resulting in altered emotional responses to speech.

Biography

We investigate the inflammatory and neurodegenerative disease multiple sclerosis. Specifically, we focus on how immune signals modulate glia function to influence both pathophysiology and repair. 

Biography

We investigate cellular properties that underlie the ability of neuronal ensembles to extract and encode information and their experience-dependent maturation using brainstem circuits that compare information between the two ears that are critical for sound localization and may be disrupted in children with central auditory processing disorder. 

Dr. Winters's Lab Website

Biography

We investigate gait, locomotor biomechanics, and motor development in primates and other mammals.
Dr. Young's Lab Website